A research of postoperative cognitive dysfunction of elderly patients after general anesthesia combined with nerve block or not for total knee arthroplasty

postoperative cognitive dysfunction of elderly patients after general anesthesia combined with nerve block or not for total knee arthroplasty

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-15005897

Enrollment

Unknown

Registered

2015-01-28

Start date

2015-01-29

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction of elderly patients after total knee arthroplasty

Interventions

general anesthesia combined with nerve block group:general anesthesia combined with nerve block

general anesthesia group:general anesthesia

Eligibility

Sex/Gender

All

Age

68 Years to 90 Years

Inclusion criteria

Inclusion criteria: 68 years or older for total knee arthroplasty

Exclusion criteria

Exclusion criteria: Anesthesia within the past 180 days; Baseline Mini Mental State Examination (MMSE) score less than 23; Preexisting neuropsychiatric diseases; Unable to speak Chinese.

Design outcomes

Primary

Measure	Time frame
Trail Making Test Part A;Digit Symbol Substitution Test;Auditory Verbal Learning Test;Mini Mental State Examination;The Confusion Assessment Method;S100 beta;	—

Countries

China

Contacts

Public ContactXi Siwei

siwei1990@126.com+86 13701646312

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026