The therapeutic effect of statins on patients with depression after acute coronary syndrome

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-14005672

Enrollment

Unknown

Registered

2014-12-15

Start date

2014-12-14

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression secondary to coronary artery disease

Interventions

Higher dose statins intervention group:Rosavastatin calcium 20mg/d p.o.

sertraline:sertraline 25-50 mg/d p.o.

Control group:Rosavastatin calcium 5mg/d p.o.

Eligibility

Sex/Gender

All

Age

30 Years to 90 Years

Inclusion criteria

Inclusion criteria: Diagnostic criteria of ACS was based on guidelines. STEMI, NSTEMI, and UA patients were included in this clinical trail. Diagnostic criteria of depression was based on the PHQ-2 and PHQ-9 questionnaire.

Exclusion criteria

Exclusion criteria: Previous history of mental illness, a tendency to commit suicide, severe hepatic and renal dysfunction, anxiety state (HAD-A score more than 7), left ventricular ejection fraction(LVEF) less than 0.45, hemodynamic instability, LDL-c more than 3.37mmol/L, allergic to statins or sertraline

Design outcomes

Primary

Measure	Time frame
Degree of depression;	—

Countries

China

Contacts

Public ContactWenlin Ma

mawenlin@medmail.com.cn+86 18621892703

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026