Portal Hypertension
Conditions
Interventions
A:partial splenic embolization with percutaneous emboIization of gastroesophageaI varices
B:transjugular intrahepatic portosystemic shunt with percutaneous emboIization of gastroesophageaI varices
C:transjugular intrahepatic portosystemic shunt
Sponsors
the First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. be able to sign up the informed consent and comply by the plan pf treatment and follow-up; 2. acute or recent(in 3 months) variceal hemorrhage; 3. Large varices confirmed by contrast enhanced computed tomography and/or endoscopy.
Exclusion criteria
Exclusion criteria: 1. liver cancer or other malignant tumors; 2. previous TIPS, surgical shunt or spleen resection; 3. more than 50% stenosis or obstruction, and thrombosis or cavernous transformation of portal vein; 4. polycystic disease of liver; 5. failure of heart, lung or kidney, or other complications which treatment contradicted to the trail' management; 6. hepatic encephalopathy; 7. MELD (model for end-stage liver disease) score by 4 or more or Child-Pugh C or higer degree; 8. uncontrolled infection, especially biliary infection; 9. Budd-Chiari syndrome; 10. contraindications to anticoagulation drugs; 11. reject to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| variceal rebleeding; | — |
Secondary
| Measure | Time frame |
|---|---|
| procedural complications;variceal recurrence;hepatic encephalopathy;mortality;MELD score changing by 4 or more points or Child-Pugh score by 2 or more; | — |
Countries
China
Contacts
Public ContactHan Xin-Wei
Outcome results
None listed