Overactive Bladder
Conditions
Interventions
A:Wegnlitong Capsules
B:Extended-release Tolterodine
C:Wegnlitong Capsules & Extended-release Tolterodine
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) female, age ranging from 18 to 75; 2) diagnosed as OAB at out-patient departments; 3) urinary frequency and urinary urgency, with or without urgency urinary incontinence; 4) urine volume per micturition < 200ml; 5) diagnosed as traditional Chinese medicine syndrome of dampness heat and blood stasis (represent yellow and slimy tongue fur); 6) urine routine test excluded urinary tract infection and represented no sign of urinary tract infection 4 weeks before screening; 7) patients were able to complete micturition diary with good compliance.
Exclusion criteria
Exclusion criteria: 1) with severe cardiac diseases and arrhythmia; 2) with severe hepatic and renal diseases, in which case aspartate aminotransferase, alanine aminotransferase and creatinine are 1.5 times greater than the upper limit of normal reference range; 3) with contraindication of anticholinergic therapy, such as urinary retention, gastric retention, uncontrolled angle-closure glaucoma and allergy to Wenglitong capsules; 4) acute urinary tract infection with symptoms during screening period; 5) hematuria with unknown cause, cancer, interstitial cystitis, neurogenic bladder, bladder outlet obstruction, urethral catheterization, brain trauma, thyroid diseases, diabetes mellitus and other diseases which researchers recognized as unsuitable to be included in this trial; 6) pregnancy, lactation or prepared to pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overactive bladder symptom score;Micturition diary; | — |
Secondary
| Measure | Time frame |
|---|---|
| Type-B ultrasonic checks; | — |
Countries
China
Contacts
Public ContactMujun Lu
Outcome results
None listed