chronic obstructive pulmonary disease
Conditions
Interventions
1:tiotropium 18ug qd
2:budesonide/formoterol 160ug/4.5ug q12h
3:budesonide/formoterol 320ug/9ug q12h
4:tiotropium 18ug qd + budesonide/formoterol 160ug/4.5ug q12h
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. patients diagnosed as chronic obsructive pulmonary disease of group D; 2. patients have been clinically stable for at least 3 months prior to the study; 3.aged older than 40 years; 4. patients did not take long-acting beta 2-adrenoceptor agonists or long-acting muscarinic antagonist or inhaled corticosteroids or oral corticosteroids in the previous 1 month before study entry; 5. patients volunteer for this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. with any infection in the previous 1 month before study entry; 2. with any concomitant confounding disease: cancer, tuberculosis, connective tissue disorders, heart failure, hepatic or renal diseases; 3. with asthma, bronchiectasis, silicosis or any other lung disease; 4. with prostatic hyperplasia or bladder neck stenosis; 5. with narrow angle glaucoma; 6. allergy to study medications; 7. with reading or communication disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein;interleukin-6;interleukin-8;interleukin-10; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine;fibrinogen;tumor necrosis factor-alpha; | — |
Countries
China
Contacts
Public ContactDeyun Cheng
Outcome results
None listed