Chronic subdural hematoma
Conditions
Interventions
Group 1:oral administration of Atorvastatin
Group 2:oral administration of Atorvastatin and Dexamethasone
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. To be aged from 18 to 90 years old, both gender; 2. CT scan reveals supratentorial, unilateral or bilateral chronic subdural hematoma (MRI scan is warranted if diagnosis is difficult); 3. The midline shift to less than 1 cm, exclude the patients with the risk of cerebral hernia; 4. Markwalder's Grading Scale and Glasgow Coma Scale (MGS-GCS) lower than Grade 3; 5. Attending physician makes a judgment that cerebral hernia would not occur and surgical operation might not be performed in a short time. Conservative treatment is adopted; 6. Patients have never undergo surgery on the hematoma; 7. Patient fully understood the nature of the study, and voluntarily participates and signs informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergic to the statin and dexamethasone or its ingredients; 2. Hematoma caused by tumors, blood and other known comorbidities; 3. Abnormal liver function; Uncontrolled hepatitis and other liver diseases, as well as suffering from other disease may interfere the study; 4. Patients have been on oral Statin in the past four weeks; 5. Patients have been on oral Steroids for a long time; 6. Diabetes diagnosis and patients with poorly controlled blood glucose; 7. Participate in clinical trials in the past four weeks; 8. Failure of completing the trial by poor compliance; 9. Hypertension is extremely high risk; 10. Merge infection without under control; 11. For any reason, the researchers believe that the case is not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the quantity change on CT before and after treatment hematoma; | — |
Secondary
| Measure | Time frame |
|---|---|
| the symptoms improve before and after every stage treatment;Blood routine before and after every stage treatment;Liver function before and after every stage treatment;Blood coagulation function;GOSE prognostic score;Daily life ability score (ADL score); | — |
Countries
China
Contacts
Public ContactWang Dong
Tianjin Medical University General Hospital
Outcome results
None listed