Effects of Intravenou dexmedetomidine on cognitive function and cerebral injury after carotid endarterectomy

Effects of Intravenou dexmedetomidine on cerebral oxygen metabolism and cognitive function after carotid endarterectomy

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-14005517

Enrollment

Unknown

Registered

2014-11-20

Start date

2014-11-22

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carotid endarterectomy

Interventions

Control group :received an equal volume of normal saline

group DEX:additional infusion of dexmedetomidine (0.3 ug/kg loading dose, during 10min before induction of anesthesia, followed by 0.3ug/kg-1/h-1 as maintenance dose) was administered until 30 min bef

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: The patients aged 65-80years, and had carotid stenosis of 70% or greater, and all the patients should write the informed consent.

Exclusion criteria

Exclusion criteria: 1) The patients who had a history of severe cerebral infarction, and the MMSE scores below 20; 2) The patients who had Serious heart valve disease, liver, kidney and respiratory insufficiency; 3) The patients who had severe hearing or visual impairment, or can't understand MMSE scale; 4) The patients who had a history of cerebrovascular, neck vascular surgery.

Design outcomes

Primary

Measure	Time frame
initial Mini-Mental State Examination (MMSE) scores;Brain derived neurotrophic factor;Inflammatory cytokines;malondialdehyde;Blood gas analysis;	—

Countries

China

Contacts

Public ContactGe Yali

happygezi81@163.com+86 18051061135

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026