Clinical observation of the effect of subarachnoid injection ephedrine under small doses of spinal anesthesia with maternal supine hypotension

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-14005477

Enrollment

Unknown

Registered

2014-05-25

Start date

2014-08-07

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Maternal supine hypotension syndrome after spinal anaesthesia

Interventions

C:0.25% bupivacaine 5mg + ephedrine 10mg

D:0.25% bupivacaine 5mg + ephedrine 25mg

A:0.25% bupivacaine 5mg

B:0.25% bupivacaine 5mg + ephedrine 5mg

Eligibility

Sex/Gender

All

Age

25 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Have indications for combined spinal-epidural anesthesia and elective cesarean; 2. ASA classfing of I-II; 3. Primipara; 4. Aged from 25y to 35y.

Exclusion criteria

Exclusion criteria: 1. Primipara combined with hypertension or pregnancy-induced high blood pressure or other cardiovascular diseases; 2. Who had spinal anesthesia history; 3. Twin or multiple pregnancy.

Design outcomes

Primary

Measure	Time frame
Maximum fell block plane;The time of perfect block;The time of block decrease;Maternal blood pressure and heart rate;fetal heart rate;Neonatal heart rate;Ephedrine dosage;Administrated the additional lidocaine dosing and timing;The local anesthetics serum concentration of Maternal and fetal;The catecholamine concentrations maternal blood and fetal cord blood after delivery before and after Anesthesia;Fluids, urine output, blood loss;Using B-ultrasonography detect the inner diameter of maternal blood vessels before and after anaesthesia;	—

Measure

Time frame

Maximum fell block plane;The time of perfect block;The time of block decrease;Maternal blood pressure and heart rate;fetal heart rate;Neonatal heart rate;Ephedrine dosage;Administrated the additional lidocaine dosing and timing;The local anesthetics serum concentration of Maternal and fetal;The catecholamine concentrations maternal blood and fetal cord blood after delivery before and after Anesthesia;Fluids, urine output, blood loss;Using B-ultrasonography detect the inner diameter of maternal blood vessels before and after anaesthesia;

—

Countries

China

Contacts

Public ContactWang Sheng

iamsheng2006@163.com+86 18935701573

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026