primary Sjogren syndrome
Conditions
Interventions
treatment group:hydroxychloroquine+Jiedu Tongluo Shengjin Decoction
Sponsors
Yueyang Hospital of Integrative Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: -Age 18-65 years old -In line with the 2002 European and American Collegiate classification standard of Sjogren syndrome 1. Diagnosis and differentiation of Chinese medicine conforms to diagnosis and typing standard of dry disease in the "Shanghai City TCM disease diagnosis and treatment routine" (deficiency of fluid of lung and stomach, yin deficiency of liver and kidney, deficiency of both qi and yin); 2. No visceral involving; 3. Baseline 8 weeks have not received glucocorticoid and immunosuppressive therapy.
Exclusion criteria
Exclusion criteria: 1. Patients under the age of 18 years or more than 65 years old; 2. Patients who use corticosteroids and other immunosuppressive in nearly 1 months; 3. Combined with other connective tissue diseases; 4. The presence of Ophthalmology taboos of using hydroxychloroquine, such as retinitis pigmentosa; 5. Lesions in other organ involvement involving; 6. Combined with cardiac conduction block (PR more than at least 0.2 sec and QRS more than at least 0.08 sec); 7. Combined with cardiovascular, cerebrovascular, liver, kidney and hematopoietic system severe primary diseases; 8. Allergy and allergic to many medicines; 9. Pregnancy or prepare for pregnancy, and lactation woman; 10. The patient cannot cooperate or are in other drug trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| subjective indicators of dry mouth and dry eye;ESSDAI;the secretion of saliva flow without stimulating;Schirmer's test;Corneal fluorescein staining;Breakup time of tear film; | — |
Secondary
| Measure | Time frame |
|---|---|
| ESR;CRP;C3, C4;IgA, IgG, IgM;RF; | — |
Contacts
Public ContactLuan Xue
Outcome results
None listed