Effect of dexmedetomidine on the EC50 of propofol combined with remifentanil I-gel insertion

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPR-14005365

Enrollment

Unknown

Registered

2014-10-14

Start date

2013-03-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

elective gynecological operation

Interventions

Dex group:dexmedetomidine 1.0 ug/kg made up to 10 ml with NS, infused over a 15 minutes period using a syringe pump

Con group:NS 10 ml, infused over a 15 minutes period using a syringe pump

Eligibility

Sex/Gender

Female

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: elective gynecological surgery under general anesthesia, ASA grade I~II, Age 18-45 years.

Exclusion criteria

Exclusion criteria: 1. patients with a history or evidence of a difficult airway; 2. patients with gastro-oesophageal reflux diseases; 3. history of reactive airway disease, hepatic or renal disorders; 4. long-term use of benzodiazepines or tricyclic antidepressants, or a history of drug abuse; 5. BMI (body mass index) more than 30kg/m2.

Design outcomes

Primary

Measure	Time frame
Assessment of the I-gel insertion conditions, the target effect -compartment propofol concentration;Hemodynamic data;	—

Countries

China

Contacts

Public ContactYe Zhang

zhangye_hassan@sina.com+86 055163869480

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026