Intracranial Infection
Conditions
Interventions
Vancomycin group:Norvancomycin IV 2h, 800mg, Q8h, 21 days
Vancomycin group:Vancomycin IV 2h, 1g, Q8h, 21days
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Inclusion criteria
Inclusion criteria: 1) After neurosurgery craniotomy; 2) diagnosed as intracranial infection; 3) Aged between 18 to 65 years; 4) Have signed informed consent The diagnostic intracranial infection criteria was two or more of the following changes: (i) temperature higher than 38 or lower than 36, vomiting, headache, positive signs of meningeal irritation (nuchal rigidity, Brudzin ski's sign and Kernig's sign); (ii) positive changes in CSF specimens: white blood cell (WBC) count more than 1000*10^6 cells/L, glucose less than 2.2 mmol/L or less than 40% of serum glucose; and (iii) positive CSF cultures
Exclusion criteria
Exclusion criteria: 1) Aged 18 or above; 2) Allergic history of norvancomycin or vancomycin; 3) Before recruiting, resistance against MRSA or epidermis staphylococcus aureus antibiotics have been used within 72 hours 4) Severe cardiopulmonary, hepatic and renal insufficiency; 5) Maternal in the perinatal period 6) Refused to sign informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effect of trial antibiotics;CSF recovery time; | — |
Secondary
| Measure | Time frame |
|---|---|
| LOS in ICU and hospital;mortality;blood routine recovery time;dosage and cost of antibiotics; | — |
Countries
China
Contacts
Public ContactQiang Wang
Outcome results
None listed