acute pain
Conditions
Interventions
control group:Analgesia pump configuration: sufentanil (kg * 3) ug plus saline 295ml to 300ml
Dexmedetomidine 0.02u g/kg/h group:Analgesia pump configuration:Sufentanil (kg * 3) ug + dexmedetomidine (kg * 3) ug+ NS to 300ml
Dexmedetomidine 0.04u g/kg/h group:Analgesia pump configuration: Sufentanil (kg * 3) ug + dexmedetomidine (kg * 6) ug+ NS to 300ml
Dexmedetomidine 0.06u g/kg/h group:Analgesia pump configuration: Sufentanil (kg * 3) ug + dexmedetomidine (kg * 9) ug+ NS to 300ml
Sponsors
Liaocheng people's hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-II; 2. aged 2 to 65 years old; 3. implementation of general anesthesia and postoperative PCIA; 4. can fully communicate and communicate, can correctly use the PCIA device and the pain NRS score method; 5) to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. preoperative combined with chronic pain and long-term use of analgesic drugs; 2. severe heart, lung, liver and kidney dysfunction; 3. the history of neuromuscular diseases, endocrine system diseases, allergic diseases, and mental disorders; 4. given dexmedetomidine hydrochloride or sufentanil allergy; 5. Preoperative SBP< 100 mmHg, HR< 50 /min, II-III degree atrioventricular block, or other cardiac conduction or rhythm abnormalities; 6. preoperative use of antihypertensive drugs clonidine or other a2 adrenergic receptor agonists; 7. combined spinal anesthesia; 8. combined nerve block analgesia; 9. participating in other drug clinical study in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS;consumption of Analgesic drug; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of PCA pump presses;OAA/S;Satisfaction Assessment;Hemodynamic changes;Nausea and vomiting scores;Exhaust time; | — |
Countries
China
Contacts
Public ContactZhang Zongwang
Liaocheng people's hospital
Outcome results
None listed