By comparing with nicorandil Conventional usage, evaluate the effectiveness and safety of nicorandil sequential therapy of different dosage in patients with ST-segment elevation myocardial infarction: a randomised, controlled, singel center, superiority trial

The effectiveness on nicorandil sequential therapy of different dosage in patients with ST-segment elevation myocardial infarction: a randomised study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPC-16009477

Enrollment

Unknown

Registered

2016-10-18

Start date

2016-11-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ST-segment elevation myocardial infarction

Interventions

Group 2:nicorandil conventional usage

Group 2:nicorandil sequential therapy

Eligibility

Sex/Gender

All

Age

20 Years to 79 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. diagnosed as STEMI; 2. 20-79 years of age; 3. from onset to admission time <12h; 4. for emergency PCI treatment; 5. good compliance, signed informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1.taking sulfonylurea drugs such as gliclazide, glimepiride; 2. severe glaucoma; 3.have an allergy to niacin drug ; 4. severe liver and kidney dysfunction; 5. left main stenosis; 6. had a clear history of myocardial infarction; 7. had severe skin ulcer; 8. patients with other serious diseases or life expectancy of <12 months.

Design outcomes

Primary

Measure	Time frame
infarct size;	—

Secondary

Measure	Time frame
troponin;CK-MB;LVEF;Seattle angina scale score;6min walking test;CCS classification;Major adverse cardiac events, MACE;	—

Countries

China

Contacts

Public ContactDongdong Sun

Department of Cardiology, Xijing Hospital, Fourth Military Medical University

wintersun3@gmail.com+86 029 84775183

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026