A Pilot Study of Dual Hemispheric Theta Burst Stimulation for Chronic Post-Stroke Aphasia

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPC-15007337

Enrollment

Unknown

Registered

2015-10-31

Start date

2015-11-09

Completion date

Unknown

Last updated

2017-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aphasia stroke

Interventions

Single group:Dual Hemispheric Transcranial Magnetic Stimulation about four minutes, once a day, totally ten times

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. aged 18 or above, right-handed, Cantonese native speaker; 2. first-ever stroke (both ischemic stroke and hemorrhagic stroke) with onset time more than six months and left middle cerebral artery (LMCA) territory involved; 3. recordable motor evoked potential (MEP) in either hand; 4. mild to moderate motor-dominant aphasia (National Institution of Health Stroke Scale (NIHSS) Part 9 = 1); 5. capable of undergoing language assessment (NIHSS Part 1a=0, 1b=0 or 1 and 1c= 0 or 1); 6. the patient or his/her legally acceptable representative is willing to provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. personal history of epilepsy; 2. metallic implants in any part of body; 3. implanted cardiac pacemaker, defibrillator, medication pump or any other implanted electronics; 4. severe skull fracture, serious head injury, history of brain or spinal cord surgery; 5. brain tumor on CT/MRI; 6. administration of drugs that potentially lower seizure threshold; 7. active malignancy; 8. severe co-existing systemic diseases, severe dementia or psychosis; 9. inability to be followed up at regular interval; 10. pregnancy or breast-feeding; 11. pure word deafness; 12. diagnosed dementia; 13. clinical evidence of depression; 14. clinical sign of hearing or visual impairment without aids; 15. alcohol abuse and drug addiction.

Design outcomes

Primary

Measure	Time frame
changes in scores of language assessment, measured by Cantonese version of Western Aphasia Battery;	—

Secondary

Measure	Time frame
changes in subscores of language assessment, measured by Cantonese version of Western Aphasia Battery;	—

Countries

China

Contacts

Public Contactka Sing Lawrence Wong

The Chinese University of Hong Kong

ks-wong@cuhk.edu.hk+852 26323144

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026