stroke, aphasia
Conditions
Interventions
Single arm:transcranial magnetic stimulation about four minutes once a day, totally twenty times.
Sponsors
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. aged 18 or above, right-handed, Cantonese native speaker; 2. first-ever ischemic stroke with onset time less than 21 days and left middle cerebral artery (LMCA) territory involved; 3. recordable motor evoked potential (MEP) in either hand; 4. mild to moderate motor-dominant aphasia (National Institution of Health Stroke Scale (NIHSS) Part 9 = 1); 5. capable of undergoing language assessment (NIHSS Part 1a=0, 1b=0 or 1 and 1c= 0 or 1); 6. the patient or his/her legally acceptable representative is willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. personal history of epilepsy; 2. metallic implants in any part of body; 3. implanted cardiac pacemaker, defibrillator, medication pump or any other implanted electronics; 4. severe skull fracture, serious head injury, history of brain or spinal cord surgery; 5. brain tumor on CT/MRI; 6. administration of drugs that potentially lower seizure threshold; 7. active malignancy; 8. severe co-existing systemic diseases, severe dementia or psychosis; 9. inability to be followed up at regular interval; 10. pregnancy or breast-feeding; 11. pure word deafness; 12. diagnosed dementia; 13. clinical evidence of depression; 14. clinical sign of hearing or visual impairment without aids; 15. alcohol abuse and drug addiction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in scores of language assessment, measured by Cantonese version of Western Aphasia Battery.; | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in sub AQs of CWAB measured by Cantonese version of Western Aphasia Battery.; | — |
Countries
China
Contacts
Public Contactka Sing Lawrence Wong
Chinese University of Hong Kong
Outcome results
None listed