knee osteoarthritis
Conditions
Interventions
Group 1:Intra-articular dextrose injection 16 weeks
Group 2:Intra-articular normal saline injection 16 weeks
Sponsors
Professor Regina Wing Shan SIT
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. To be aged from 45 to 75 years old; 2. Diagnosis of knee OA based on clinical criteria as defined by the American Rheumatology Association; 3. Have experienced moderate to severe anterior knee pain for at least 3 months, defined as a score of 3 or more (0-6 ordinal response scale) on the question "What is the average level of your left/right knee pain?" 4. Failed 6 months of usual care.
Exclusion criteria
Exclusion criteria: 1. History of corn allergy; 2. Previous operation either open or arthroscopic, on the referring knee; 3. Pregnancy; 4. Body mass index >=35 kg/m2; 5. Patients on anti-coagulant therapy; 6. Prior knee prolotherapy; 7. Any knee injections within 3 months; 8. Inflammatory or post-infectious knee arthritis; 9. Significant effusion as defined by a balotteable patella; 10. Co-morbidity severe enough to prevent participation in the study protocol like attendance at scheduled injection appointments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) WOMAC score of both intervention and control group; | — |
Secondary
| Measure | Time frame |
|---|---|
| (2) VAS 0-100 mm;(3) 30 second chair stand performance test;(4) timed up and go test;(5) EQ5;(6) the pattern of analgesic consumption with the statement "I take analgesic drugs like (name of analgesics) daily, as needed, none at all.";(7) treatment satisfaction will be assessed at 52 weeks with the question “Will you recommend the therapy to others with knee OA like yours? (yes/no)”.;40 meter fast-paced walk test; | — |
Countries
China
Contacts
Public ContactProfessor Regina Wing Shan SIT
Division of Family Medicine and Primary Health Care, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong
Outcome results
None listed