Post-operative Pulmonary Complications
Conditions
Interventions
Penehyclidine hydrochloride:Penehyclidine hydrochloride (penehyclidine hydrochloride 0.5 mg/0.5 ml + normal saline 5.5 ml) were administered by inhalation every 12 hours from the night before surgery
Placebo control:Placebo control (water for injection 0.5 ml+ normal saline 5.5 ml) were administered by inhalation every 12 hours from the night before surgery to the second day after surgery.
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
51 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age>50 years old; (2) Scheduled for upper abdominal surgery or thoracotomy. For those having laparo-/thoracoscopic surgery, the expected incision length was >=5 cm; (3) Expected operation time >= 2h; (4) Patients with high risk of postoperative pulmonary complications according to the Canet risk score (the Canet risk score>=45).
Exclusion criteria
Exclusion criteria: (1) patients who refuse to participate in this study or patients who cannot cooperate with the inhalation; (2) patients with ASA grade>=IV or the anticipated life time<=24h; (3) patients with prostate hypertrophy or glaucoma; (4) patients who had myocardial infarction, cardiac dysfunction or fast ventricular arrhythmia within the year; (5) patients who had been given beta 2 receptor activator, M receptor blockers and/or glucocorticoids within a month before surgery; (6) patients with serious renal dysfunction who need dialysis before the surgery; (7) patients with serious liver dysfunction (the grade of Child-Pugh C); (8) patients with cerebral stroke within three months before surgery; (9) patients who had participated in other research in the recent month or still within the six half-time of other research drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative mortality of 30 days;Duration of hospital stay after surgery;Other postoperative complications;Time to onset of postoperative pulmonary complications;Number of individual pulmonary complications; | — |
Countries
China
Contacts
Public ContactWang Dongxin
Peking University First Hospital
Outcome results
None listed