Neurophysiological and biochemical mechanism involve in the efficacy of cognitive-coping therapy for obessive-compulsive disorder

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IPC-15005969

Enrollment

Unknown

Registered

2015-02-10

Start date

2013-05-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-compulsive disorder

Interventions

Pharmacoterapy plus cognitive-coping therapy:Pharmacoterapy plus cognitive-coping therapy

Pharmacotherapy plus psychological support:Pharmacotherapy plus psychological support

Control:No intervention or cognitive-coping therapy

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: All patients met the OCD criteria of the Diagnostic and Statistical Manual of Mental Disorders (4th edition, test revision)(DSM-IV-TR) and had Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score more than 16.

Exclusion criteria

Exclusion criteria: Exclusion criteria included the presence of severe cognitive deficits or some other axis I diagnosis (including schizophrenia, substance abuse, or developmental disabilities; but not including depression or anxiety disorder) or being <18 years old.

Design outcomes

Primary

Measure	Time frame
Yale-Brown Obsessvie Compulsive Scale;fMRI;	—

Secondary

Measure	Time frame
Serotonin;mRNA;Protein;	—

Countries

China

Contacts

Public ContactHu Xianzhang

huxianzhang@yahoo.com+1 301-294-2135

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 24, 2026