non-cystic fibrosis bronchiectasis
Conditions
Interventions
Experimental group:Routine treatment combining with the therapy of bronchoalveolar lavage and local drug injection (Amikacin)
Sponsors
Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male or female aged between 18 to 80 years; 2. Confirmed diagnosis of non-cystic fibrosis bronchiectasis; 3. Acute exacerbation of bronchiectasis; 4. Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing, 6-minute walk test (6MWT), etc.
Exclusion criteria
Exclusion criteria: 1. Active bleeding without control; 2. Receiving nasal or facial surgery recently; 3. With severe cardio-pulmonary dysfunction, such as left heart failure, unstable arrhythmia, etc.; 4. Pregnant women; 5. with other respiratory diseases: such as active pulmonary tuberculosis, non-tuberculosis mycobacteria (NTM) pulmonary disease, pulmonary aspergillosis; 5. Be allergic to amikacin or not tolerant to nebulised amikacin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LCQ score;mMRC score;SGRQ score;PFT;The rate of sputum bacterial clearance; | — |
Contacts
Public ContactJinfu Xu
Outcome results
None listed