Depression
Conditions
Interventions
Control group:Placebo
Zinc group:Supplement zinc 20mg/d
Folic acid group:Supplement folic acid 0.2mg /d
Zinc+Folic acid group :Supplement zinc 20mg/d+ folic acid 0.2mg /d
Sponsors
Qingdao University
Eligibility
Sex/Gender
All
Age
19 Years to 21 Years
Inclusion criteria
Inclusion criteria: "Self rating Depression Scale" (SDS) standard scores between 53-62.
Exclusion criteria
Exclusion criteria: With a history of one or more manic or hypomanic episodes; Patients with cerebrovascular disease, cardiovascular disease and Alzheimer's disease; Patients with schizophrenia and other mental disorders; Women preparing for pregnancy, pregnancy and lactation; People who could not be evaluated because of acute symptoms of depression; People with dutch act ideation, mental motor inhibition, loss etc.; People in the treatment of diseases and taking various drugs; People involved in other research projects; People with malignant tumor or intestinal polyposis etc.; People taking nutritional supplements containing folic acid or zinc in the past 2 months; People with serum zinc lower than 10-10.7 mol/L (65-70 g/dl); People with serum folic acid lower than 6.8nmoL/L (3ng/ml).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Zinc;Zinc of white blood cell;Blood folic acid;Folic acid of red blood cell;Brain derived neurotrophic factor; | — |
Countries
China
Contacts
Public ContactDou Mei
Outcome results
None listed