dysphagia
Conditions
Interventions
virtual lesion group :continuous theta burst stimulation
patient group :transcranial magnetic stimulation
Control:conventional treatments
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) virtual lesion group: in good health, aged 20 to 70 years old, without any swallowing disorder or swallowing discomfort, no speech and cognitive dysfunction, no neurologic illness, no structural disorders of the head and neck, without metal implants in head and eyes, able to follow the instructions for inspection, voluntarily sign informed consent. (2) patient group: first-ever cerebral infarction and clinical stroke diagnosis consistent with the World Health Organization definition of stroke, CT/MRI confirmed for unilateral cerebral hemisphere supratentorial lesions, clinically significant dysphagia and videofluoroscopic evidence of abnormal swallowing, aged 40–70 years, onset of stroke within 3–12 months of study, voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: (1) virtual lesion group: taken gastrointestinal prokinetic agents, antacids, etc. within the month before participate the study; obvious abnormal result of high-resolution manometric esophageal examination; pregnant women, nursing mothers, or menstruating women; refused to sign the informed consent; (2) patient group: bilateral or subtentorial stroke, previous history of stroke, brain tumor or brain traumaor other neurological or psychiatric disorders; prior history of dysphagia; the presence of cognitive impairment or aphasia; severe cardiac, respiratory or renal disease; fail to cooperate with examination and treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| motor evoked potential;pharyngeal pressure waveform;upper esophageal sphincter pressure waveform;center network of swallowing; | — |
Countries
China
Contacts
Public ContactYue Lan
Outcome results
None listed