Type 2 Diabetes
Conditions
Interventions
Impaired Fasting Glucose Patients with WTP Diet:Whole grains, traditional Chinese medicinal foods and prebiotics diet
Impaired Fasting Glucose Patients with Usual Care:Routine diet guidance for diabetes patients
Impaired Glucose Tolerance Patients with WTP Diet:Whole grains, traditional Chinese medicinal foods and prebiotics diet
Impaired Glucose Tolerance Patients with Usual Care:Routine diet guidance for diabetes patients
Impaired Fasting Glucose and Glucose Tolerance Patients with WTP Diet:Whole grains, traditional Chinese medicinal foods and prebiotics diet
Impaired Fasting Glucose and Glucose Tolerance Patients with Usual Care:Routine diet guidance for diabetes patients
New diagnosed T2D patients receiving WTP Diet:Whole grains, traditional Chinese medicinal foods and prebiotics diet
New diagnosed T2D patients receiving usual care:Routine diet guidance for diabetes patients
Patients with diabetic complications receiving WTP Diet :Whole grains, traditional Chinese medicinal foods and prebiotics diet
Patients with diabetic complications receiving usual care :Routine diet guidance for diabetes patients
Sponsors
Shanghai First Peoples Hospital, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Subjects with (1)normal glucose metabolism; (2)patients with normal PBG but FBG is higher than 5.6mmol/L;(3)patients with normal FBG but PBG is higher than 7.8mmol/L; (4)patients whose FBG is higher than 5.6mmol/L and PBG is higher than 7.8mmol/L; (5)New diagnosed T2D patients; (6)T2D patients with complications whose HbA1c is between 6.5% and 12.0%; 2. Aged 35-70 year old; 3. Han people living in the local more than five years and having constant residence; 4. Having not attend any other research projects; 5. Having good memory and motility; 6. Having healthy mentality and self-care ability; 7. Providing written informed consent and others.
Exclusion criteria
Exclusion criteria: 1. More than one of diabetes antibodies (IAA, ICA and GAD) was detected as positive and the patient was diagnosed as type 1 diabetes; 2. With severe diabetes complications, e.g. leg ulcers, severe liver and kidney damage, severe neurological diseases and severe retinopathy; 3. Blood pressure more than 180/110mmHg, triglyceride more than 2.3mmol/L and cholesterol more than 6.2mmol/L; 4. Antibiotic or weight-loss drugs usage continuously for more than 1 month; 5. Pregnancy or planning to become pregnant; 6. Intemperance (drinking more than 5 times in one week and drinking more than 100g spirit, 250g rice wine or 5 bottles of beer); 7. With severe mental disease in last 6 months; 8. Received drug therapy aim at the following diseases, e.g. cholecystitis, peptic ulcer, urinary tract infection, acute pyelonephritis, urocystitis or hyperthyreosis; 9. Received gastrointestinal surgery except for appendicitis or hernia surgery; 10. With chronic persistant hepatitis, severe hepatic diseases, e.g. liver cirrhosis or cooccurence of positive HBsAg and abnormal hepatic transaminase; 11. With IBD or Cushing's syndrome; 12. With pituitary dysfunction; 13. With severe organic disease, e.g. cancer, coronary heart disease, myocardial infarction and cerebral apoplexy; 14. With infectious disease, e.g. phthisis and Aids; 15. Physical Disability or self-care disability or disability of recalling clearly and answering questions caused by any other reasons; 16. Anemia: HbA1c less than 10g/dl; 17. Slimmer using any weight loss drugs or surgical methods in last 3 months; 18. With acute/chronic renal failure; 19. With obvious dyskinesia; 20. Without enough time taking part in this project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c;Ankle brachial index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thyroid function;Urine Routine;blood routine;Blood chemistry for kidney function;Blood chemistry for liver function;Gut microbiota function;The metabolism of gut microbiota;The compositioin of gut microbiota;Intestines secrete peptide;Drug Usage;CEA;Blood presure;Hipline;Waistline;Body Mass Index;Weight;High Density Lipoprotein;Low Density Lipoprotein;Triglyceride;Cholesterol;Glycated Serum Protein;HOMA-beta Index;HOMA-IR index;OGTT Insulin;ECG;albumin creatinine ratio;24 hour dynamic electrocardiogram;Carotid artery B-mode ultrasonography;Fundus examination;Vibration perception threshold;Pulse wave velocity;Resting heart rate;Respiration interval;Heart rate variation in recumbent-upright position;Valsalva index;Blood pressure in recumbent-upright position;Blood pressure change in grip strength tests; | — |
Countries
China
Contacts
Public ContactYongde Peng Liping Zhao
Shanghai First Peoples Hospital, Shanghai Jiao Tong University
Outcome results
None listed