Hypertenison
Conditions
Interventions
Case series:three consecutively allocated 8-week treatment cycles with irbesartan, amlodipine and hydrochlorothiazide
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with blood pressure=140/90mmHg for =3 times on separate days, without history of antihypertensive treatment; 2. Aged 18-80 years old; 3. In Tibetan nationality; 4. Patients whose total cardiovascular risk are mild or moderate according to hypertensive guideline released by European society of hypertension[8]: Grade 1 hypertension (SBP 140–159 and/or DBP 90–99mmHg) and= 2 risk factors (Table 1); Grade 2 hypertension (SBP 160–179 and/or DBP 100–109mmHg) and = 1 risk factors (Table 1); 5. Willing to participate with informed consent signed.
Exclusion criteria
Exclusion criteria: 1. Secondary hypertension; 2. Blood pressure = 180/110 mmHg; 3. History of cerebrovascular events: Ischemic stroke, cerebral hemorrhage, transient ischemic attack; 4. Coronary heart disease: Prior myocardial infarction, history of angina, myocardial revascularization with PCI or CABG; 5. Pulse pressure = 60mmHg (in the elderly); 6. Echocardiographic LVH: men > 115g/m2, women > 95 g/m2; 7. Carotid wall thickeningL IMT > 0.9mm or plaque; 8. Arterial stiffness; 9. Ankle-brachial index 30 mg/24 h, or albumin–creatinine ratio 30-300mg/g; 14. Advanced retinopathy: haemorrhages or exudates, papilloedema; 15. Pregnant or with pregnancy plan; 16. Cancer; 17. Severely hepatic dysfunction; 18. Mental sickness without civil capacity; 19. Contraindications for irbesartan, amlodipine, and hydrochlorothiazide; 20. Under treatment of medications interfering BP, e.g. corticosteroid, contraceptive, et al; 21. Unable to be followed-up; 22. Other situations not appropriate for study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bood pressure reduction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure control rate;Adverse event; | — |
Countries
China
Contacts
Public ContactXiaoping Chen
West China Hospital, Sichuan University
Outcome results
None listed