large cerebral infarction
Conditions
Interventions
1:conventional dehydration
2:Be intravenously administered 0.2 mg nalmefene hydrochloride injection
Sponsors
the First Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria of cerebral infarction caused by occlusion of the middle cerebral artery trunk according to the Fourth National Academic Conference on the Diagnosis of Cerebrovascular Disease,and confirmed by CT and/or MRI of the head; 2. Onset time = 3d; 3. First onset; 4. Aged 18-80 years; 5. Provision of wirtten informed consent by patients relatives or legal surrogate.
Exclusion criteria
Exclusion criteria: 1. Receive arterial thrombolysis treatment before treatment; 2. Presence of new infarcts or incidence of hemorrhagic infarct during the process of treatment; 3. Severe damage to other organs; 4. With cognitive disorder, neuropsychiatric disorder, drug abuse or alcoholism; 5. Recently taken or are taking immunosuppressive drugs; 6. Maligant tumor; 7. Pregnant or lactating woman; 8. Participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effective rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS score;GCS;Serum level of MMP-9 at;MRI perfusion imaging of the head; | — |
Countries
China
Contacts
Public ContactHou Weichen
the First Hospital of Jilin University
Outcome results
None listed