circulation and postoperative throat pain
Conditions
Interventions
Control Group:None
Oral containing Group:Oral containing dyclonine
Coated Group:Dyclonine coated
Oral containing and coated Dyclonine Group:Oral containing and coated Dyclonine
Sponsors
Guangzhou First People's Hospital, Guanzghou Medical University, Guangzhou, China
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Aged from 18 to 70 years old, male or female; (2) Patients were conformed to ASA I or II; (3) Patients with elective general anesthesia surgery; Operation time is estimated to be less than 120 min (3 minutes from anesthesia to extubation); (4) Platelet count is normal; (5) Patients clearly understand and voluntarily participate in the study; and informed consent was signed by their own or legal guardian.
Exclusion criteria
Exclusion criteria: (1) Patients with local surface anesthesia contraindications; (2) Patients with neck surgery (such as: thyroid subtotal resection, neck tumor removal, etc.) (3) Hepatitis B virus carriers or patients with hepatitis B , hepatitis C,immunodeficiency, positive HIV antibody test result, positive syphilis check result; (4) Patients with a serious history of cardiovascular disease (such as: heart failure and arrhythmia, etc.); angina (unstable angina) due to heart coronary blood insufficient supply , or with myocardial infarction in the last 6 months; (5) Patients with hypertension without satisfactory control of blood pressure (resting systolic pressure = 160mmHg, and / or diastolic blood pressure = 100 mmHg); (6) Patients with systolic blood pressure <90 mmHg, and / or diastolic blood pressure <60 mmHg; (7) Patients with craniocerebral injury, intracranial hypertension, cerebral aneurysm, cerebrovascular accident history and central nervous system diseases; (8) Patients with psychiatric disorders (schizophrenia, mania, bipolar abnormalities, mental disorders, etc.) and drug history and cognitive dysfunction; (9) Patients with porphyria, or history of epilepsy; (10) Patients with severe pulmonary dysfunction, severe superior vena cava obstruction syndrome, or suspected aortic aneurysm; (11) Patients with airway stenosis; (12) Patients with history of asthma; (13) Patients were assessed as difficult airway; patients with intubation more than once; (14) Extreme body failure; (15) Patients with history of alcohol or abuse; (16) Patients with abnormal coagulation, bleeding tendency (such as active hemoptysis) or are receiving thrombolytic or anticoagulant therapy; (17) Pregnancy, lactating women; (18) Patients is allergic or intolerant to the drugs used in the program; (19) Other reasons that the investigators believe that they should not participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure, rhythm during Intubation and extubation period;Adverse incidence of physical examination indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Agitation score during intubation and extubation;Sore throat in postoperative 24h and 48h;Oral suction function;Time from the end of the operation to the patient's eyes and time from the end of the operation to the tracheal catheter withdrawal;Adverse reactions of intubation;Patients' comfort and satisfaction.; | — |
Countries
China
Contacts
Public ContactShouzhang She
Guangzhou First People's Hospital, Guanzghou Medical University, Guangzhou, China
Outcome results
None listed