Bronchiolitis
Conditions
Interventions
Treatment group:Inhalation of 2.5 mg (0.5 mL) salbutamol dissolved 4.0 mL hypertonic (3%) saline
Control group:Inhalation of 2.5 mg (0.5 mL) salbutamol dissolved in 4.0 mL normal (0.9%) saline
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: The wheezing infants suffered from viral bronchiolitis for the first time. The patients with bronchiolitis were ranked mild to moderate according to the clinical score system as follows: 1. Respiratory rate: 0 points: less than 30 breaths/min; 1 point:31–45 breaths/min; 2 points: 46–60 breaths/min; 3 points: >60 breaths/min; 2. Wheezing: 0 points: none; 1 point: terminal expiratory or heard only with stethoscope; 2 points: entire expiration or audible on expiration without stethoscope; 3 points:inspiration and expiration without stethoscope; 3. Retractions:0 points: none; 1 point: intercostal only; 2 points: tracheosternal; 3 points: severe with nasal flaring; 4. General condition: 0 points: normal; 3 points: irritable, lethargic, poor feeding. Referring to the total clinical score, the disease severity can be divided into the following ranks: 0–4.9, mild; 5–8.9, moderate; and 9–12 points, severe disease.
Exclusion criteria
Exclusion criteria: The exclusion criteria were as follows: age > 24 months, previous episode of wheezing, chronic cardiac and pulmonary disease, immunodeficiency, accompanying respiratory failure, requiring mechanical ventilation, inhaling the nebulized 3% hypertonic saline solution and salbutamol 12h before treatment, and premature infants born at less than 34 weeks'gestation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wheezing remission time;Cough remission time;The moist crackles disappeared;The average length of hospital stay; | — |
Countries
China
Contacts
Public ContactZhengxiu Luo
Children's Hospital of Chongqing Medical University
Outcome results
None listed