irritable bowel syndrome and functional dyspepsia
Conditions
Interventions
experimental group:pinaverium
control group:pinaverium and pantoprazole
Sponsors
Wuhan Union Hospital of Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent form; 2. Aged between 18 and 65 years and the sex is not limited; 3. In accordance with irritable bowel syndrome diagnostic criteria of the Roman III and IV, patients are diagnosised diarrhea-predominant irritable bowel syndrome; 4. Meet the diagnosis of functional dyspepsia in Rome III criteria; 5. The upper abdominal ultrasound, esophagogastroscopy and colonoscopy were performed in the past year in a tertiary A hospital to exclude the organic and metabolic diseases; 6. The electrocardiogram was conducted in the center during the past month and the QT phase was within the normal range.
Exclusion criteria
Exclusion criteria: 1. A history of abdominal operation; 2. Concomitant medication acting on or influencing the gastrointestinal system (such as proton-pump inhibitors, H2 blockers, cholagogues, prokinetic agents, NSAIDs, theophylline) in past 5 days; 3. Combined with other gastrointestinal functional diseases(functional diarrhea, gastroesophageal reflux disease etc.); 4. Combined with other diseases such as heart, brain, liver, renal, hematopoietic, metabolic and systemic diseases(thyroid diseases, systemic sclerosis, systemic lupus erythematosus etc.), or other serious diseases affecting the survival of the patients; 5. The level of ALT, AST or total bilirubin were exceeded 1.5 times than the normal limit; 6. Combined with severe psychological disorders requiring medication; 7. Pregnant, breastfeeding or plan to pregnant; 8. Allergic to pinaverium or pantoprazole; 9. Taken apart in other clinical study within 3 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IBS-SSS;FD-SSS;Bristol stool type and frequency; | — |
Secondary
| Measure | Time frame |
|---|---|
| single symptom of IBS;single symptom of FD; | — |
Countries
China
Contacts
Public ContactJinsong Liu
Wuhan Union Hospital of Huazhong University of Science and Technology
Outcome results
None listed