COPD
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. COPD group: (1) Aged 40-80 years old, male and femal; (2) confirmed diagnosis of COPD based on the diagnostic criteria, the COPD status had to be stable, with at grade III-IV; (3) In TCM syndrome differentiation criteria for lung, spleen and kidney deficiencies associated with retention of phlegm and blood stasis. 2. Healthy control group: (1) Aged 40-80 years old, male and female, physical examination was normal and no smoking history; (2) No acute or chronic respiratory diseases; (3) No cardiovascular diseases and diabetes mellitus; (4) No autoimmune diseases; (5) No allergic or hereditary allergic diseases; (6) Antibiotics and corticosteroids were not used in the past 1 month; (7) No obvious abnormality in chest X-ray examination; (8) Normal blood routine and blood ester and lung function.
Exclusion criteria
Exclusion criteria: 1. Patients were diagnosed with acute upper respiratory tract infections in the past two weeks; 2. Exacerbations in COPD; 3. Systemic corticosteroids were used in the past month; 4. Although the airflow obstruction, but clinical diagnosis of bronchial asthma, pulmonary tuberculosis, cystic fibrosis, diffuse bronchiolitis, bronchiolitis obliterans; 5. Patients were diagnosed with serious cardiovascular, liver, kidney or hematopoietic diseases; patients were diagnosed with psychiatric disorders; 6. Pregnant or lactating women; ?Unwilling to cooperate and completely unable to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| COPD assessment test;mMRC;6-minute walking distance;Interleukin 8;Interleukin 17A;tumor necrosis factor a;transforming growth factor ß1;LTB4; | — |
Countries
China
Contacts
Zhangzhou Hospital of Traditional Chinese Medicine of Fujian Province