Knee osteoarthritis
Conditions
Interventions
The treatment group:The MEMS micro-needle to Promote penetration and Layers adjusting extemal application technique
The control group:Diclofenac diethylamine emulsion
Sponsors
Jiangsu Province Hospital Of TCM
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the western medicine diagnostic criteria for knee osteoarthritis,and meet the following conditions: (1) Radiological disease classification in grade III-IV; (2) Joint functional classification in grade III-IV; (3) The WOMAC total is between 80 and 120; 2. Aged greater than or equal to 40 years; 3. After 7 days washout period, if the patients with chronic knee osteoarthritis have received other nonsurgical treatments; 4. Informed consent. ;Inclusion criteria: 1. Meet the western medicine diagnostic criteria for knee osteoarthritis,and meet the following conditions: (1) Radiological disease classification in grade III-IV; (2) Joint functional classification in grade III-IV; (3) The WOMAC total is between 80 and 120; 2. Aged greater than or equal to 40 years; 3. After 7 days washout period, if the patients with chronic knee osteoarthritis have received other nonsurgical treatments; 4. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Knee osteoarthritis associated with acute synovitis; 2. Knee joint tuberculosis, tumour, rheumatoid arthritis; 3. Complications affecting the joints, such as psoriasis, syphilitic mental derangement, ochronosis, metabolic bone disease, acute trauma and so on; 4. Nearly 60 days took the systemic or joint cavity hormone therapy; Nearly 3 months, evaluated the knee joint with cavities injection or arthroscopy; 5. The skin of wound was damaged, or other diseases affected treating with the local administration of wound, such as skin diseases and so on; 6. Allergy sufferers; 7. Women during the lactation, pregnancy or planning a pregnancy; 8. Patients who are participating in other drug clinical trials; 9. In addition to the OA, Taking painkillers for other chronic or recurrent pain; 10. According to the researchers' judgment, there are other lesions or conditions that reduce the possibility of entering the group or complicating the group, such as frequent changes in the working environment, etc.;Exclusion criteria: 1. Knee osteoarthritis associated with acute synovitis; 2. Knee joint tuberculosis, tumour, rheumatoid arthritis; 3. Complications affecting the joints, such as psoriasis, syphilitic mental derangement, ochronosis, metabolic bone disease, acute trauma and so on; 4. Nearly 60 days took the systemic or joint cavity hormone therapy; Nearly 3 months, evaluated the knee joint with cavities injection or arthroscopy; 5. The skin of wound was damaged, or other diseases affected treating with the local administration of wound, such as skin diseases and so on; 6. Allergy sufferers; 7. Women during the lactation, pregnancy or planning a pregnancy; 8. Patients who are participating in other drug clinical trials; 9. In addition to the OA, Taking painkillers for other chronic or recurrent pain; 10. According to the researchers' judgment, there are other lesions or conditions that reduce the possibility of entering the group or complicating the group, such as frequent changes in the working environment, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC;Joint functional classification;;WOMAC;Joint functional classification; | — |
Secondary
| Measure | Time frame |
|---|---|
| X-ray classification;MRI classification;Routine blood;CRP;blood lipids;Liver and kidney function;MMPs;OPG;RANKL;TIMP-1;IL-6;TNF-a;;X-ray classification;MRI classification;Routine blood;CRP;blood lipids;Liver and kidney function;MMPs;OPG;RANKL;TIMP-1;IL-6;TNF-a; | — |
Countries
China
Contacts
Public ContactPeimin Wang;Peimin Wang ;
Jiangsu Province Hospital of TCM ;Jiangsu Province Hospital of TCM
Outcome results
None listed