propofol induced body movements during general anesthesia induction in children patients and its potential pre-treatment methods
Conditions
Interventions
Mixed group and Propofol group:Propofol combined with lidocaine (propofol plus 1 ml of lidocaine per 20 ml)
Midazolam group and propofol group:Before 2 minute of anesthesia induction pretreatment of midazolam0.1mg/kg
Sufentanil group and propofol group:Pretreatment of sufentanil0.3ug/kg.min
Dexmedetomidine group and propofol group:4ug/kg.min pre-pumped dexmethomidine for 10 minute
Ketamine group 1 and propofol group:Pretreatmen of ketamine of 0.5 mg/kg
Ketamine group 2 and propofol group:Pretreatmen of ketamine of 0.6 mg/kg
Ketamine group 3 and propofol group:Pretreatmen of ketamine of 0.7 mg/kg
Ketamine group 34and propofol group:Pretreatmen of ketamine of 0.8 mg/kg
Sponsors
The Second Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
4 Years to 50 Years
Inclusion criteria
Inclusion criteria: children undergoing elective surgery under general anesthesia; ASA I-II grade; Aged 4-12 years old; cooperation with the establishment of placement of intravenous cannulation; capable of a commucation with experimenters; adults undergoing elective surgeryunder general anesthesia; ASA I-II grade; Aged 18-50 years old; surgery is expected no more than 3 h.
Exclusion criteria
Exclusion criteria: Obesity (BMI>30); with mental illness or cerebral disease;movement disorders; heart, lung, liver serious abnormal renal function; a allergy history to drug used or their composition; a history of convulsive seizures or asthma; and (1) those participate in other clinical trials of patient; (2) Other reasons are not suitable for clinical subjects according to the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of pain in anesthesia induction;whether there is a body reaction;BIS values during anesthesia induction (every 5s);BIS values and time at the beginning of body movement;BIS value and time at the end of body movement;The severaty of body movement; | — |
Secondary
| Measure | Time frame |
|---|---|
| BIS value at the initial of induction;the lowest BIS values and time during induction; | — |
Countries
China
Contacts
Public ContactSiyuan Li
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed