Major depressive disorder
Conditions
Interventions
B group:B capsule
A group:A capsule
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. TAble to provide informed consent; 2. Men or women aged 18-50 years; 3. A primary psychiatric diagnosis of major depressive disorder (MDD), by Diagnostic and Statistical Manual-5th ed (DSM-5) using the MINI; 4. HAMD total score=21; 5. No significantly modification of their diet from the time they sign consent to the end of study participation.
Exclusion criteria
Exclusion criteria: 1. Suffering from other serious somatic diseases or comorbidities; 2. Patients with serious nervous system disease; 3. Patients in accordance with diagnostic standards of other mental illness; 4. Patients who need to take benzodiazepine every day, and who currently need to be treated by electroconvulsive therapy or have received electroconvulsive therapy in the past 6 months; 5. Pregnant women or lactating women, women with pregnancy plans during the trial period (12 months), women with a high risk of pregnancy but without taking any contraceptive measures; 6. Patients with apparent suicide attempt or suicidal behavior; 7. Any condition or medicines that may have an effect on biomarkers (within 1 week of the screening period or during whole trial period): long-term, regular use of NSAIDs, COX-2 inhibitors, immunosuppressant, steroids, interferon, chemotherapeutics, anticoagulants, malignancy, active autoimmune diseases, inflammatory bowel diseases, etc; 8. Allergy history of PUFA; 9. Intake of Fish oil more than 3g per day or eat fatty fish more than 3 times a week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD;HAMA;BDI;SAS; | — |
Countries
China
Contacts
Public ContactJindong Chen
The Second Xiangya Hospital of Central South University
Outcome results
None listed