Alzheimer's disease
Conditions
Interventions
Mild-1 group:placebo
Mild-2 Group:FNS medication
MCI-1 Group:FNS medication
MCI-2 Group:Placebo
Sponsors
the Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. the normal control group(NC): using clinical dementia rating scale (CDR) to measure subjects' memory, direction, judgment and problem solving skills, social affairs, family life, hobbies, CDR =0. MCI group(MCI): using CDR to measure subjects' memory, direction, judgment and problem solving skills, social affairs, family life, hobbies, CDR= 0.5. The mild dementia group (mild AD): using CDR to measure subjects' memory, direction, judgment and problem solving skills, social affairs, family life hobbies CDR= 1.
Exclusion criteria
Exclusion criteria: 1. Severe vision or/and hearing impairment, can not complete cognitive function tests; 2. Anxiety, depression, severe insomnia recently; 3. cognitive dysfunction caused by Lack of folate, vitamin B12, thyroid disease, severe cardiopulmonary, liver, kidney, and other diseases of the nervous system?diseases (Lewy body dementiaCorticobasal ganglion degenerationHuntington's choreaProgressive supranuclear palsy; 4. Alcohol or drug dependence, a history of severe head injury; 5. past medical history of cerebrovascular disease (such as ischemic cerebral apoplexy, cerebral hemorrhage, moderate or severe leukoaraisosis, etc.); 6. Intracranial infection, viral encephalitis, CJD, AIDS, neurosyphilis); 7. Individuals with metal dentures,, bracket and other metal objects; 8. The subjects refused to participate the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive scales;blood Aß42 and AGEs;BOLD-fMRI, ALFF; | — |
Countries
China
Contacts
Public ContactXiaofeng LI
the Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed