Chronic spontaneous urticaria
Conditions
Interventions
Group B:Placebo
Group A:Gubenxiaozhen granule
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the chronic spontaneous urticaria diagnosis creteria; 2. Male and female aged 18 to 65 years old; 3. Patients with syndrome pattern of Wei qi deficiency; 4. UAS7=7; 5. To be able to and willing to provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1. The occurrence of chronic urticaria is severe, such as the appearance of chest stuffy, wheezing, breathing difficulties, and the choking of the laryngeal mucosa. Accompanied by high fever, cold war,tachycardia, etc.; 2. Pregnant,lactating women or pregnancy is planned in half a year; 3. Patients with psychiatric disorders; 4. Patients with other skin diseases that require treatment currently, With history of primary cardiovascular, respiratory, digestive, urinary, endocrinologic and hematologic diseases, which can't be controlled through ordinary treatments.patients with malignant tumor. Patients with clinical test results listed below: AST or ALT 3 times more than normal upper limit; Creatinine 3 times more than normal upper limit;Or any other abnormal laboratory test results, assessed by investigators, that are not suitable for this clinical study; 5. Topical treatments with antihistamines or chinese medicine within 1 week; Oral hormones and other immunosuppressive drugs, immunoglobulins and autohemotherapy within 4 weeks; biological therapy or inject glucocorticoid drugs within 12 weeks; 6. Allergic to this drug ingredient; 7. Participating other clinical trials or participated within 3 months; 8. Workers engaged in highly concentrated attention (driving machines, cars, ships, high-altitude work, mechanical assignments, and precision instruments) 9.Patients who are unfit to enter the group according to doctor's judgment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weekly Urticaria Activity Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weekly itch score;Weekly hive score;Propotion of a reduction of weekly UAS to 40% of baseline;time to relapse;relapse rate;Dermatology Quality Life Index;The use of western medicine; | — |
Countries
China
Contacts
Public ContactLu Chuanjian
Guangdong Provincial Hosptial of Chinese Medicine
Outcome results
None listed