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Hydromorphine via HO-1 upregulation improves the balance of mitochondrial dynamics and alleviate CO2 pneumoperitoneum related lung injury

Hydromorphine via HO-1 upregulation improves the balance of mitochondrial dynamics and alleviate CO2 pneumoperitoneum related lung injury

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-17011733
Enrollment
Unknown
Registered
2017-06-21
Start date
2017-06-26
Completion date
Unknown
Last updated
2017-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing laparoscopic total hysterectomy

Interventions

Experimental group:hydromorphine treatment
Control group:Sevoflurane relies on inhalation anesthesia

Sponsors

Department of Anesthesiology, Tianjin Nankai Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Women aged 30-65 yearsweighed 40-70kg with ASA status I or II, scheduled for elective laparoscopic total hysterectomy of<3h duration at Tianjin Nankai hospital between June 2017 and March 2018 were enrolled in this study. All patients have no history of chronic pain, mental illness, and a long-term history of pain reliever.

Exclusion criteria

Exclusion criteria: Exclusion criteria included cardiovascular disease (hypertension, arrhythmia or myocardial ischaemia), haemodynamic instability (active bleeding, hypovolaemia or loss of body fluid), asthma or chronic obstructive pulmonary disease, allergy to the study drug and body mass index 30 kg/m2.

Design outcomes

Primary

MeasureTime frame
Cdyn;RI;

Countries

China

Contacts

Public ContactYu Jianbo

Department of Anesthesiology, Tianjin Nankai Hospital

yujianbo11@126.com+86 13652033134

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026