poor ovarian response
Conditions
Interventions
treatment group:Oral Dingkun Dan for three months
control group:No intervention
Sponsors
The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. The patients aged 25 to 38 years old; 2. Regular menstrual cycle (25-35 days); 3. Patients who consistent with poor ovarian respond diagnosis ; 4. Patients who met the infertility criteria (if the age<35 years old, subfertility=1 year; If the age =35 years old, subfertility=6months. The infertility duration will not betaken into account if there is any causes to disorder the transport of the gamete, such as oviduct obstruction, after tubal sterilization, etc.); 5. Patients who prepare to receive IVF/ICSI; 6. Willing to accept the test and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. With other endocrine diseases and autoimmune diseases, such as polycystic ovary syndrome, hyperlipidemia, Kaohsiung hormone, thyroid dysfunction, diabetes; 2. With other reproductive system diseases such as endometriosis, endometrial tuberculosis, intrauterine adhesions, uterine fibroids (submucous uterine myoma or not submucousmyoma but the diameter>4cm or oppress to endometrium), uterine malformation (uterus duplex, bicornuate uterus, unicornous uterus, septet uterus, etc.) hydrosalpinx; 3. With severe primary disease of internal medicine, surgery and psychiatric; 4. The female or her husband merged with genetic or acquired diseases; 5. Intake hormone drugs or Chinese herb (such as contraceptive drugs, ovulation-stimulating medicine, glucocorticoid etc) in 3 months prior to study entry; 6. Allergic to any ingredient within research drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ongoing pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| the change of serum AMH level;total gonadotropins dosage;duration of stimulation;cycle cancellation rate;the number of retrieved oocytes;high qualified embryo rate;biochemical pregnancy rate;the change of serum FSH level;the change of AFC;the change of serum E2 level;serum estradiol and progesterone level on the day of hCG administration; | — |
Countries
China
Contacts
Public ContactTian Xia
The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed