ovarian cancer
Conditions
Interventions
treatment group:apatinib combined with docetaxel
Sponsors
Changhai Hospital of Second Military Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. aged from 18 to 75 years old. 2. the pathological diagnosis of epithelial ovarian cancer. 3. by detecting specific drug resistance or a recent application progressed after taxol chemotherapy. 4. ECOG score(PS) from 0 to 2 point. 5. main viscera function is normal,t as the following requirements: (1) the blood routine examination, must be in accordance with no blood transfusion (14 days): HB=90g/L; ANC=1.5×109/L; PLT=80×109/L. (2) biochemical inspection must meet the following standards: BIL<1.5×ULN; ALT and AST<2.5×ULN; if liver metastases occured, ALT and AST<5×ULN; serum Cr=1×ULN. 6. expected lifetime=3 months. 7. agreed to participate in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. patients with hypertension, the antihypertensive drug treatment can not drop to normal range (systolic blood pressure > 140mmHg/diastolic blood pressure > 90mmHg), with a class II or higher coronary heart disease, arrhythmia (including QTc lengthened men > 450 ms, women > 470 ms) and cardiac insufficiency; 2. the influence factors of oral drug absorption, such as unable to swallow, chronic diarrhea and intestinal obstruction, etc.; 3. the patients with contraindications of apatinib or docetaxel; 4. the patients had a history of mental illness can't cooperation; 5. known allergic to the study medication; 6. patients are participanting in other drug trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;DCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;OS;QOL;ECOG score;symptoms of Ovarian cancer; | — |
Countries
China
Contacts
Public ContactYu Chaoqin
Changhai Hospital of Second Military Medical University
Outcome results
None listed