Periodontal Disease
Conditions
Interventions
The intervention group:Free periodontal treatment and oral health education
The control group:Free periodontal washing and oral health education
Sponsors
School of Public Health, Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: At least 18 years old; pre-pregnancy women who plan to conceive within one year; remaining teeth = 20; without moderate or severe dental caries; without systematic or reproductive disease; without rheumatoid arthritis; without severe cardiovascular disease; without diabetes; without hyperthyroidism and other systemic disease; without immunodeficiency diseases; planning to deliver at one of the participating hospitals; diagnosed as having periodontitis after oral examination; willing to be compliant to the follow up during the trial.
Exclusion criteria
Exclusion criteria: receiving periodontal treatment except the study; contraindication to probing in a dental examination and treatment, such as heart disorders; taking antibiotics or drugs that affect the periodontal tissue metabolism; wearing a fixed prostheses; not pregnant within 12 months after periodontal examination; multiple pregnancy; changed plan for pregnancy (not plan to be pregnant within a year); with a disease mentioned in the inclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of low birth weight;Incidence of preterm birth; | — |
Secondary
| Measure | Time frame |
|---|---|
| Prevalence of periodontal disease;Concerntration of inflammatory mediators in saliva;Concerntration of inflammatory mediators in blood;Concerntration of periodontal pathogens;Hemoperfusion function of placenta;The level of LPS;Placenta growth related RNA expression;Placenta growth factor II;MDA;SOD;GSH-Px;GSH;GSSG;Placenta VI;Placenta FI;Placenta VFI; | — |
Countries
China
Contacts
Public ContactHong Jiang
School of Public Health, Fudan University
Outcome results
None listed