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Analyze the effect of warming yang and benefiting qi on patients with allergic rhinitis based on TLR-NF-?B signal pathway and Thl/Th2 balance shift theory

Analyze the effect of warming yang and benefiting qi on patients with allergic rhinitis based on TLR-NF-?B signal pathway and Thl/Th2 balance shift theory

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-17011429
Enrollment
Unknown
Registered
2017-05-18
Start date
2017-05-20
Completion date
Unknown
Last updated
2017-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

alleigic rhinitis

Interventions

treatment group:treat with Sheti Zhiqiu herbal prescription

Sponsors

Chengdu University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) It is characterized by nasal symptoms of pruritus, sneeze, discharge, and stuffiness. The symptoms are present more one hour a day. The symptoms are present more one, and more than 3 days a week and for more than 3 weeks; (2) Turbinate mucosa is pale and swelling. There is thin excretion in nasal cavity; (3) The specific IgE examination in serum is positive; We set TCM diagnostic criteria according to the allergic rhinitis diagnostic criteria from the otorhinolaryngology of TCM. It is characterized by nasal symptoms of pruritus, sneeze, discharge, and stuffiness. The concomitant symptoms are shortness of breath, lazy speech, voice low, spontaneous perspiration, afraid of the cold, pale complexion, pale tongue, thin white fur, weak pulse.Turbinate mucosa is pale and swelling. There is thin excretion in nasal cavity. Inclusion criteria: (1) Conform to the diagnostic criteria above; (2) The aged between 18 and 60 years old; (3) The daily life is effect by the disease.

Exclusion criteria

Exclusion criteria: (1) Concomitant with other system diseases and need long-term use of certain drugs; (2) Concomitant with bronchial asthma, allergic dermatitis, or other allergic diseases; (3) Concomitant with chronic rhinosinusitis, rhinopolyp, or other nasal diseases; (4) Patients with pregnancy.

Design outcomes

Primary

MeasureTime frame
IFN-?;IL-4;TLR2;TLR4;NF-kB p50/NF-kB p-p50;NF-kB p65/NF-kB p-p65;I?B-a/p-I?B-a;iTRAQ;

Countries

China

Contacts

Public ContactPeng Shun-ling

Chengdu University of Traditional Chinese Medicine

psl6@163.com+86 18980880161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026