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Effect of remifentanil on the EC50 of propofol target-controlled infusion caused severe dysphagia

Effect of remifentanil on the EC50 of propofol target-controlled infusion caused severe dysphagia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-17011024
Enrollment
Unknown
Registered
2017-03-31
Start date
2017-02-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dysphagia

Interventions

Pure propofol TCI intravenous anesthesia group (P group):propofol TCI intravenous anesthesia
Remifentanil TCI 1 ng / ml + propofol TCI group (group R1):remifentanil TCI 1 ng / ml + propofol TCI intravenous anesthesia
Remifentanil TCI 2 ng / ml + propofol TCI group (group R2):Remifentanil TCI 2 ng / ml + propofol TCI intravenous anesthesia

Sponsors

Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Sixty one patients classified as American Society of Anesthesiologists (ASA) physical status I to II and ages 20 to 65 years who had selective gastrointestinal endoscopy in February 2017 in our hospital were recruited.

Exclusion criteria

Exclusion criteria: Patients with age 65 years old; Patients with a history of swallowing disorders and retention of nasal feeding; Pregnant patients; Patients with lung disease SpO2 <95% or needing oxygen; Patients with neurological diseases, mental illness,history of using antidepressants or type I diabetes Patients with ASA = IV, history of tracheotomy, otorhinolaryngology or radiotherapy and mouth, pharynx, esophageal cancer surgery ; Patients with major glottic abnormalities (eg, bilateral vocal cord paralysis, malignant or benign laryngeal tumors protruding on the glottis surface

Design outcomes

Primary

MeasureTime frame
Fibreoptic Endoscopic Evaluation of Swallowing, FEES;

Secondary

MeasureTime frame
Observer’s Assessment of Alertness/Sedation Scale, OAAS;

Countries

China

Contacts

Public ContactLi Yujuan

Sun Yat-sen Memorial Hospital of Sun Yat-sen University

yujuan_04@aliyun.com+86 15918734156

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026