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Prospective randomized controlled clinical trial of corticosteroid therapy for severe drug induced liver injury

Prospective randomized controlled clinical trial of corticosteroid therapy for severe drug induced liver injury

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-17010880
Enrollment
Unknown
Registered
2017-03-15
Start date
2016-06-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

severe drug-induced liver injury

Interventions

corticosteroid therapy group :corticosteroid therapy with routine medical treatment
control group: routine medical treatment

Sponsors

302th Military Hospital, PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of drug-induced liver injury; 2. Meet the diagnostic criteria of severe drug-induced liver injury; 3. Aged 18-60 years; 4. Patients willing to sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients without informed consent; 2. Patients with severe infection; 3. Patients with uncontrolled diabetes mellitus; 4. Patients with gastric and duodenal ulcer; 5. Patients with osteonecrosis of the femeral head; 6. Patients with glaucoma; 7. Patients with hemorrhage of digestive tract; 8. Special group with pregnancy and mental disorders; 9. Other patients who are not suitable for hormone therapy.

Design outcomes

Primary

MeasureTime frame
survival rate;liver function;coagulation function;—

Countries

China

Contacts

Public ContactYou Shaoli

302th Military Hospital, PLA

youshaoli1972@163.com+86 010-66933404

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026