depression
Conditions
Interventions
experimental group:Jiaotai pill + fluoxetine hydrochloride
control group: fluoxetine hydrochloride
Sponsors
Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Conform to depression diagnostic criteria of "American psychiatric diagnosis standard" Fourth Edition (DSM-IV); Accord with the diagnostic criteria of TCM syndrome of depression in disharmony of heart and kidney; HAMD 24 items score of more than 20 points and less than 35 points; Aged 18-65 years; The total score of HAMA less than 21 points, depressed mood (item 6) score more than 2 points, anxious mood (item 1) score less than 3 points; Not taking antidepressants or taking medicine but has stopped for two weeks; Sign the informed consent.
Exclusion criteria
Exclusion criteria: Secondary to other mental illnesses or physical illness and depression with severe psychotic symptoms; Severe anxiety (HAMA total score more than 21 points); Allergic constitution or previous research on drug allergy; Suicidal person; Bipolar disorder, refractory depression (application of two or more different chemical structure of antidepressants, the full amount, full course of treatment is invalid or ineffective); Intracranial cerebrovascular disease, neurodegenerative diseases, intracranial tumor, and high blood pressure, diabetes and so on of leading to brain vascular distribution or abnormal blood flow of systemic disorders; with serious diseases of other systems, and severe heart, liver and renal insufficiency; Glaucoma and epilepsy; Pregnancy or lactation or quasi pregnancy; Urine pregnancy test positive for women of childbearing age; MR inspection contraindications or cannot cooperate complete MR scan or can not adapt to the environment and noise of MRI scan; Already or will take part in other drugs observational study of patients within 30 days; Poor compliance is expected, unable to interview regularly; Researchers believe there are other conditions not suitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD;TCM syndrome score;WCST;urine metabolism;blood metabolism;functional magnetic resonance imaging;NE;DA;5-HT; | — |
Countries
China
Contacts
Public ContactZhihuan Zhou
Tianjin University of Traditional Chinese Medicine
Outcome results
None listed