spontaneous intracerebral hemorrhage
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 years old and more; 2. within 6 hours of symptom onset; 3. Acute primary ICH, hematoma in brain parenchyma or intraventricular extension, rarely into SAH, verified by CT or MRI; 4. Cerebrovascular luminal narrowing (25%-75%) demonstrated with CTA; 5. SBP is from 150 to 220mmHg (twice repeat measurements, record = 2min apart); 6. Agree to participate in this clinic trail and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Known definite indication to antihypertensive treatment (e.g. very high systolic blood pressure N220 mm Hg; hypertensive encephalopathy; aortic dissection); 2. known definite contraindication to antihypertensive treatment (e.g. the high blood pressure is caused by the increasing of the intracranial pressure which is called Cushing's response; severe cerebrovascular stenosis, severe renal failure); 3. The intracerebral hemorrhage is caused by secondary factors (e.g. intracranial aneurysm; arteriovenous malformation; tumor stroke); 4. anticoagulant correlation hemorrhage; 5. History of ischemic stroke within 30 days before SICH; 6. GCS = 5 or deep coma; 7. Disabled or with underlying diseases (e.g. known dementia, severe cardiovascular disease, kidney failure) before onset; 8. Known indication of emergency surgery (volume of supratentorial hematoma =30ml or volume of infratentorial hematoma =10ml; within 48 hours from onset; GCS=5)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| combined endpoin tof death and dependence;incidence of ischemic stroke;Health related quality of life index; | — |
Countries
China
Contacts
Public ContactChao You
West China Hospital, Sichuan University
Outcome results
None listed