refractory gastroesophageal reflux disease
Conditions
Interventions
treatment group:ShuGanHeWei granule, dissolve with warm water, two times oral daily, each time 100ml, eight weeks course of treatment
control group:Ray Bella with enteric coated tablets: each 10mg, two times a day orally for eight weeks.
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. symptoms related with gastroesophageal reflux disease, such as heartburn, vomiting stomach acid, retrosternal pain, prostrate cough, pharynx Laryngeal discomfort, GERDQ score more than 8 points; 2. endoscopy or pH and impedance monitoring for 24 hours to identify gastroesophageal reflux disease within 6 months; 3. Taking the standard dose of first generation PPI (omeprazole, lansoprazole, Pantoprazole)for 4 weeks with failure; 4. clear consciousness, subjective expression of discomfort; 5. 18-70 years of age, male and female.
Exclusion criteria
Exclusion criteria: 1. with one of the following diseases: peptic ulcer, esophageal and gastric or duodenal surgery, Zollinger Ellison syndrome, primary esophageal motility disorders (such as achalasia, scleroderma, primary esophageal spasm), upper gastrointestinal malignant lesions, drug esophagitis and psychiatric patients; 2. long-term use of other drugs for gastroesophageal reflux disease, and having not stopped a month before the study; 3. pregnant women and lactating women; 4. patients with severe cardiovascular disease or liver and kidney dysfunction (the numbers of AST, ALT, creatinine are more than one and a half times as the normal range); 5. those who can not understand the treatment or can not take medicine and the relevant inspectors on time; 6. researchers of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood test;urine test;stool test;liver function;renal function;ECG;electronic gastroscope;Gastric mucosa pathology;Clinical symptom score;SF-36 score; | — |
Countries
China
Contacts
Public ContactShengLiang Zhu
Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine
Outcome results
None listed