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The change of pharmacokinetics of single injection of ropivacaine on pleural cavity and the change of plasma concentration of repeated injection of ropivacaine on pleural cavity

The change of pharmacokinetics of single injection of ropivacaine on pleural cavity and the change of plasma concentration of repeated injection of ropivacaine on pleural cavity

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-17010560
Enrollment
Unknown
Registered
2017-02-07
Start date
2017-02-06
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

thoracoscopic surgery

Interventions

Group of single injection:single injection of 0.75% ropivacaine 15ml on pleural cavity
Group of repeated injection: injection of 0.75% ropivacaine 15ml on pleural cavity every four hours

Sponsors

The First Affiliated Hospital of Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Eligible subjects aged 18 years or older, ASA I to III, and scheduled for thoracoscopic surgery

Exclusion criteria

Exclusion criteria: Exclusion of amide local anesthetic allergies, history of thoracic operation or chest infection,chronic pain, severe central neurologic diseases,patients with liver and renal insufficiency,history of alcohol and opioid dependence, the recent use of opioid drugs or drugs interaction with ropivacaine, inability to carry out NRS test,patient who was younger than 12 years old,patients with BMI=30kg/m2 or =15kg/m2.

Design outcomes

Primary

MeasureTime frame
plasma concentration of ropivacaine;Patient’s satisfaction;

Secondary

MeasureTime frame
Pain score at different time points after operation;extra analgesic consumption;Adverse reactions;

Countries

China

Contacts

Public ContactXuzhong Xu

The First Affiliated Hospital of Wenzhou Medical University

xuzhong@263.net+86 13706657799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026