Aphasia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosed as stroke; 14 days to 6 months after stroke onset; aged from 35 to 80 years; 2. Native language is Chinese; right-handed; 3. Showing aphasia syndrome; diagnosed as non-fluent aphasia by China Rehabilitation Research Center Aphasia Examination (CRRCAE); Boston Diagnostic Aphasia Examination (BDAE) severity rating scale = 2; 4. Primary school and above education; 5. Clear consciousness; no cognition impairment; 6. Capable of cooperating 20 minutes MRI examination.
Exclusion criteria
Exclusion criteria: 1. Serious dysarthria, auditory perceptual impairments or cognition disorder, which do not allow the patients to cooperate with batteries examination; 2. Language impairments due to disturbance of consciousness or low Intelligence Quotien(IQ); 3. Learning disability and language function defect due to congenital or childhood diseases; 4. Serious function damage of organs like heart, liver and kidney, and researchers consider not suitable to the study; 5. Patients who are accepting transcranial direct current stimulation therapy, or taking piracetam, donepezil, memantine, bromocriptine, galanthamine, and are not allowed to stop the therapy; 6. Existence of contraindication of MRI, for example, cardiac pacemaker operation, percutaneous coronary intervention (PCI) or Coronary Artery Bypass Grafting(CABG).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of Aphasia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Language Function;Magnetic Resonance Imaging;Cognitive Ability;Neurological Deficits;Activity of Daily Living;Quality of Life;Severity of Depression; | — |
Countries
China
Contacts
Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine