alzheimer‘s disease
Conditions
Interventions
acupuncture group:acupuncture treatment three times per week
donepezil hydrochloride group:once daily, 5 mg/day for the first 4 weeks and 10 mg/day thereafter
Sponsors
First Teaching Hospital Of Tianjin University Of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
54 Years to 87 Years
Inclusion criteria
Inclusion criteria: Diagnostic criteria designed to identify patients with probable AD were developed by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimers Disease and Related Disorders Association criteria (NINCDS-ADRDA). The patients included in this study were required to have a MMSE score between 10 and 23, a 17-item Hamilton Depression Scale score =17, a Hachinski Ischemic Scale (HIS) score=4, and have a reliable caregiver who is able to accompany the participant to all study visits
Exclusion criteria
Exclusion criteria: Individuals were excluded if they had evidence of other diseases which could lead to dementia other than AD; significant unstable psychiatric or neurologic disorders; clinically relevant uncontrolled or unstable gastrointestinal, renal, hepatic, endocrine or cardiovascular disease; clinically significant obstructive pulmonary disease; B12 or folic acid deficiency; alcoholism or drug misuse or current systemic illness influencing cognitive assessment; a history of hematologic and oncologic disorders in the past two years. Subjects could not participate if they had received any treatments which probably improve cognitive function and known sensitivity to acupuncture. Patients were also excluded from the study if they were incapable of giving informed consent or participated in any tests within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer’s disease Assessment Scale-Cognitive Subscale;Clinician’s Interview-Based Impression of Change-Plus Caregiver Input; | — |
Secondary
| Measure | Time frame |
|---|---|
| 23-Item Alzheimer's disease Cooperative Study Activities of Daily Living Scales;Neuropsychiatric Index;plasma Aß40;plasma Aß42;plasma Aß Oligomer;urine Aß40;urine Aß42;Faeces Aß40;Faeces Aß42; | — |
Countries
China
Contacts
Public ContactJingxian Han
First Teaching Hospital Of Tianjin University Of Traditional Chinese Medicine
Outcome results
None listed