Breast cancer
Conditions
Interventions
Group B:external beam radiotherapy + interstitial brachytherapy
Sponsors
China-Japan Union Hospital of Jilin University
Eligibility
Sex/Gender
Female
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 30 to 75 years, the patient's ECOG performance status is 0 to 2, or KPS score is more than 70; 2. The patient's life expectancy is greater than 5 years,the other diease should consider; 3. 0 (DCIS),I, II (size=<3cm) stage breast cancer; 4. The patient has histologic confirmation of diagnosis of DCIS or invasive breast cancer; 5. The breast surgery is segment resection and negative of surgical margin, the first surgery is positive of surgery and secondary surgery is negative of surgical margin; 6. Axillary nodes is negative after axillary lymph node dissection; 7. The operation cavity of patient is clearly visible; 8. No radiotherapy contraindications.No hematopoietic function, heart, lung, liver, kidney dysfunction and immune deficiency; 9. The patient is capable of understanding and complying with the protocol and has signed the informed consent document.
Exclusion criteria
Exclusion criteria: 1. Male breast cancer; 2. III, IV stage breast cancer; 3. Suspected patients is not confirm by pathology; 4. Non epithelial malignant tumors, for example, sarcoma or lymphoma; 5. Multicenter tumor in more than one quadrant in breast or single lesion is more than 4cm; 6. Nipple Paget's disease; 7. Patients with a history of prosthesis implantation; 8. The patient has radiation therapy at the tumor region; 9. The patient has a serious concomitant medical condition including collagen vascular disease, idiopathic dermatomyositis, active cutaneous lupus, scleroderma, systemic lupus erythematosus; 10. Patient is pregnant or lactation woman; 11. Patient is mental disease or nervous system diseases; 12. The patient has participated in clinical studies of non-approved experimental agents or procedures within 4 weeks; 13. Failure to follow-up after treatment; 14.The data is missing or incomplete.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Breast cancer recurrence;Local control rate;Normal tissue side effects;Local beauty effect;Longterm survival;Quality of life; | — |
Countries
China
Contacts
Public ContactCheng Guanghui
China-Japan Union Hospital of Jilin University
Outcome results
None listed