chronic rhinosinusitis
Conditions
Interventions
Histamine stimulation group:Histamine stimulation
Azelastine hydrochloride Group:Treatment with azelastine hydrochloride
Allergen stimulation group:Allergen stimulation
Bacterial stimulation group:Bacterial product stimulation and treatment in cells culture
Virus stimulation group:Viral product stimulation and treatment in cells culture
Sponsors
Hong Haiyu
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Adult patients(18-60 years old) diagnosed with CRSwNP and CRSsNP, according to the Chinese and European Position Paper on Rhinosinusitis and Nasal Polyps, were recruited and they had undergone functional endoscopic sinus surgery (FESS) as part of the management for their disease at the Otolaryngology and Head Neck Surgery Department of the 5th Affiliated Hospital of Sun Yat-sen University.
Exclusion criteria
Exclusion criteria: Patients were excluded from the study if they had treatment with antibiotics or corticosteroids within a 4-week period before surgery, unilateral disease, allergic fungal rhinosinusitis, antrochoanal polyps, or cystic fibrosis.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Epithelial cytokines;marker of mucosal epithelial pathway; | — |
Primary
| Measure | Time frame |
|---|---|
| Th2 inflammatory factors;Th1 inflammatory factors;Th17 inflammatory factors;marker of Apoptosis;marker related mucosa; | — |
Countries
China
Contacts
Public ContactHong Haiyu
5th Hospital Affiliated with Sun Yat-sen University
Outcome results
None listed