Allergic respiratory inflammation
Conditions
Interventions
Placebo group:Placebo
Specific immunotherapy group:Dust mite drops
Sponsors
Huashan Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients in Shanghai with 2 or more of the following symptoms (watery anterior rhinorrhea, sneezing, nasal obstruction and nasal pruritis) for > 1 hour on most days, and with edema of inferior turbinate and watery secretion in the common meatus according to anterior and posterior rhinoscopy, and with a positive skin prick test response to dust mite and abnormal serum dust mite specific IgE levels (= 0.35 kU/L), and with ages between 18 and 75, male or female
Exclusion criteria
Exclusion criteria: Allergic rhinitis patients in Shanghai with a negative skin prick test response to dust mite and normal serum dust mite specific IgE levels (< 0.35 kU/L), or with intermittent or persistent moderate to severe asthma, or with long-time treatment of oral H1 antihistamine, or with treatment of systemic corticosteroids within a month, or with chronic obstructive pulmonary disease, or with severe cardiac diseases, or with cirrhosis, or with uremia, or with contraindication of corticosteroids treatment, or with allergy to glycerol, or with pregnancy, or with malignant tumors, or with contraindications of dust mite drops treatment including respiratory infection or inflammation with fever, asthma attack, severe acute or chronic diseases, inflammatory diseases, multiple sclerosis, autoimmune diseases, active period of pulmonary tuberculosis, severe psychiatric disorders, ß blockers for hypertension or glaucoma, angiotensin converting enzyme inhibitor, acute or chronic cardiovascular insufficiency, severe renal insufficiency, or with experiences of participating in other clinical trials within 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rhinoconjunctivitis quality of life questionaire;Visual Analogue Scale;Forced expiratory volume in one second; | — |
Countries
China
Contacts
Public ContactLin Lin
Huashan Hospital of Fudan University
Outcome results
None listed