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Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass

Comparison of the myocardial protective effect of sevoflurane versus propofol in patients undergoing heart valve replacement surgery with cardiopulmonary bypass

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-16009979
Enrollment
Unknown
Registered
2016-11-23
Start date
2014-11-28
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Valvular heart diseases

Interventions

Group sevoflurane:inhaled sevoflurane
Group propofol:IV infusion of propofol

Sponsors

Affiliated Hospital of North Sichuan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All patients were American Society of Anaesthesiologists physical status II to IV, aged between 40- 65 year, New York Heart Association classification of cardiac function I to III, ejection fraction less than 40%, no history of nervous system disease and normal audition.

Exclusion criteria

Exclusion criteria: hypertensive disease, coronary artery disease, diabetes, chronic obstructive pulmonary disease, infective endocarditis, hematogenic and immune systemic disease; perioperative steroid therapy; presence of any contraindication to the use of propofol or sevoflurane

Design outcomes

Primary

MeasureTime frame
cardiac troponin I;

Countries

China

Contacts

Public ContactYang Xiao Lin

Affiliated Hospital of North Sichuan Medical College

yang_xl_yang@126.com+86 13990826183

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 10, 2026